May 23, AM. Daniel Spratt, MD. Prostate Cancer. Basic Science and Laboratory Research. Cancer Research. Cancer: Cancer Types. The 5-alpha reductase type I1 gene is one of several that Ross's group is investigating for possible effects on testosterone secretion and metabolism and other androgen activity. He said they have found some forms of this gene that are unique to African-Americans and a few that are unique to Asian-Americans as well. Differences in prostate cancer incidence among blacks, whites, and Asian- Americans might also be influenced by variations in androgen receptor, the protein that moves androgens around in prostate cells.
The AR gene is polymorphic, having a particular sequence of bases that is repeated from eight to 30 times in different individuals. Evidence from several research groups suggests that longer repeat lengths are associated with lower AR activity, while shorter repeat lengths are related to greater AR activity.
A study found that the most common repeat length was 17 in African-Americans, 21 in whites, and 22 in Asian-Americans. Among environmental factors, diet—especially fat—seems the most likely to play a part in the ethnic variations in prostate cancer incidence, scientists said.
In a study headed by Whittemore, researchers found a positive association between fat intake and prostate cancer risk in blacks, whites, and Asian- Americans see Journal, May 3, The data showed that African-Americans on average consumed morecalories than whites or Asian-Americans and that a higher percentage of those calories came from fat. But dietary fat intakes by themselves are not enough to explain an appreciable fraction of the differences.
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Sign In or Create an Account. Sign In. Advanced Search. All men are at risk for prostate cancer. Out of every American men, about 13 will get prostate cancer during their lifetime, and about 2 to 3 men will die from prostate cancer. The most common risk factor is age. The older a man is, the greater the chance of getting prostate cancer. Some men are at increased risk for prostate cancer.
Some people with prostate cancer report having other family members with a history of prostate cancer. A study into the heredity of prostate cancer found 86 new genetic risk variants. The study found that men of African ancestry had an estimated mean genetic risk score GRS more than two times higher than men of European ancestry. Below is a list of risk factors that might account for the more aggressive prostate cancer in Black people. Learn more about prostate exams and what to expect here.
Prostate cancer can remain symptomless for many years because the tumor growth is relatively slow and does not push on structures that can cause pain. Prostate cancer can progress to an advanced stage before a person notices any symptoms. The best way to identify prostate cancer is with early screening. When prostate cancer does cause symptoms, a person might notice :.
Learn more about advanced prostate cancer here. The Centers for Disease Control and Prevention indicate that all males between years should consider PSA screening and have regular prostate exams.
Although prostate cancer is rare in males under 45 years , a article indicates that Black males at high risk should consider prostate screening at around this age.
These screening tests can raise any clinical suspicion of prostate cancer. A prostate biopsy is almost always needed to confirm the diagnosis. Like all cancers , prostate cancer occurs when cells in the prostate grow out of control. This happens when there are changes in the DNA of prostate cells. Some potential causes of prostate cancer include inherited genes that increase the risk of developing cancer and acquired mutations, from exposure to toxic chemicals, for example.
Learn more about prostate cancer and its causes here. The score ranges from 2—10, and a specialist determines the score by assessing the cells from the biopsy tissue.
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