Hi danielt ,. Thanks for writing about this topic and asking the question about nattokinase. From what I gathered through read the forum, the Serrapeptase dose that most seem to on is around , SPU.
Hi all — a friend suggested serrapeptase one who has no connection to any IPF groups and after doing some Google searches, it seems to function to break up scar tissue.
Curious also about what dosage for adding nattokinase to my regimen? Thanks for writing — this seems to be a hot topic as of late! A few other folks have been asking about the dosages of Nattokinase, although no one seems to have a recommended dose as you say. Thanks for sharing your experience! I know others are always interested in hearing if there are supplements or other aids that can help us living with IPF. Do you find the Natto has been helping as you hoped it would over the years?
I began taking it, berberine, and a vitamin K complex after a heart attack as an alternative to being on Plavix back in Hi maynard ,. Thank you so much for taking the time to share this information and type it all out — I have no doubts that it will be helpful for some folks in our community.
I have unfortunately taken a decline as well due to pneumonia and the flu. I hope you can recover and get back to your baseline again soon. Thanks again for sharing all the information about the supplements, I know many people who believe in the benefits of these. Hang in there and feel free to write us anytime. Pulmonary Fibrosis News Today is strictly a news and information website about the disease.
It does not provide medical advice, diagnosis or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.
This site is strictly a news and information website about the disease. Toggle navigation. Search for: Search Search. Nattokinase — What dose? This topic has 10 replies, 5 voices, and was last updated 1 year, 9 months ago by Charlene Marshall. January 16, at am Daniel T Participant. In alternative medicine, nattokinase is believed to benefit people with heart and vascular diseases, in part by breaking down blood clots that can impede circulation. Among the conditions nattokinase is purported to prevent or treat are:.
To date, there are few studies that strongly support these claims. That is not to say that promising research doesn't exist; it is simply that most of the studies are small and often poorly designed.
Here are a few worth considering. Deep vein thrombosis is the medical term used to describe a blood clot in a deep vein, usually a leg.
It tends to affect older people who are obese and have underlying circulatory problems. A study published in Scientific Reports notes that a single milligram mg oral dose of nattokinase was able to break down fibrin—a protein involved in blood clotting—more effectively than a placebo.
It also acted as a potent anticoagulant blood thinner , reducing the concentration of a blood-clotting protein known as factor VIII. The research suggests that nattokinase supplements may provide protection against DVT by preventing the formation of clots.
While the results are promising, the conclusions are limited by the small size of the study. Moreover, the participants recruited for research 12 healthy young men are in a demographic that is among the least likely to develop DVT. Further research would be needed to see if the same results can be replicated in higher-risk groups. Atherosclerosis, also referred to as the hardening of arteries, is caused by the buildup of fatty plaques on the arterial walls.
A study from China involving 76 adults with atherosclerosis reported that participants given a mg daily dose of nattokinase over 26 weeks experienced a Additionally, nattokinase increased the level of "good" HDL cholesterol , though simvastatin did not. However, simvastatin was far more effective in reducing total cholesterol, triglycerides , and "bad" LDL cholesterol , reductions of which are vital to the prevention of cardiovascular disease.
As contradictory as these findings seem, they highlight how little scientists understand the mechanism of action of nattokinase. Further research is needed to identify how nattokinase works and its implication in preventing heart attacks, stroke, and other conditions related to atherosclerosis.
Cardiovascular disease and brain health are closely linked. In recent years, there have been suggestions that nattokinase may have neuroprotective properties that halt disease progression in people with ischemic stroke. A study in the journal Stroke reported that nattokinase, given by injection, may improve blood flow to the brain following a stroke. By injecting lab mice with three doses of nattokinase prior to an induced stroke, scientists found that smaller vessels in the brain remained unblocked, limiting the spread of tissue damage.
Confirming a similar effect in humans requires additional research. The ability to break down fibrin referred to as fibrinolysis makes nattokinase an ideal candidate for research—not only with respect to stroke but other conditions influenced by fibrinolysis impairment, including Alzheimer's disease.
But that doesn't mean that it is without concerns. Because nattokinase can influence blood circulation and chemistry, it should be used with caution in certain groups, namely:. Nattokinase should also be stopped no less than two weeks prior to a scheduled surgery to reduce the risk of excessive bleeding. Due to the lack of research, nattokinase should be not be used in children or during pregnancy or breastfeeding.
There is little data as to the long-term effects of nattokinase. In the United States, nattokinase is found almost exclusively in capsule or tablet form. In vitro experiments experiments performed outside a living body suggest that nattokinase directly digests fibrin, and a few interventions do note that oral ingestion of nattokinase results in decreased thrombus formation.
Nattokinase can be metabolized into bioactive peptides that also induce a factor tissue plasminogen activator which can subsequently also have fibrinolytic effects, so although the overall effect fibrinolysis causing less clotting potential appears to exist the underlying mechanisms are not fully elucidated.
The breakdown products of nattokinase, following heat or acid destruction, are bioactive peptides that may also reduce blood pressure via reducing renin activity and angiotension II. With respect to effect on triglycerides and cholesterol, nattokinase and its bioactive peptides all appear to be wholly inactive. When looking at human intervention research, there appears to be a minor blood pressure reducing effect associated with nattokinase supplementation.
Although there is limited evidence to support the fibrinolytic effects in humans following oral consumption, the trials using nattokinase in isolation are either limited in statistical power or they used nattokinase with other agents the most convincing study currently used pycnogenol alongside nattokinase. Overall, although the enzymatic activity and pharmacodynamics of nattokinase are novel, there is not enough evidence to support the usage of nattokinase over other supplemental or pharmacological options.
Especially in regard to using an agent as prophylactic, aspirin is much more well researched and no comparative evidence exists right now comparing nattokinase to said reference drug. There is not enough evidence to suggest the optimal dose of oral nattokinase, but studies in humans tend to use around mg or 5, FU Fibrinolysis Units daily, usually divided into two separate doses taken with meals. Become an Examine Member to get access to the latest research.
Understand the whole body of nutrition and supplement evidence at a glance. The Human Effect Matrix summarizes human studies to tell you what effects Nattokinase has on your body, how much evidence there is, and how strong these effects are. Excluded due to being confounded with Pycnogenol [1].
To unlock the full archives of our Study Database and research analyses, become an Examine Member today. As nattokinase may thin the blood, it should not be paired with other blood thinning agents such as Aspirin or Warfarin. Get our free 5-day course on the essentials of supplementation. At Examine, our incentives line up with yours — getting unbiased information.
Join over , people who have learned about effective versus overrated supplements, tips for buying supplements, and how to combine supplements for safety and efficacy.
Our independent, unbiased approach reveals what works and what's a waste of time and money. Arm yourself with the knowledge you need to make the right decisions about your health. Click here to see the full set of research information and references for Nattokinase. If using any pharmaceuticals or drugs given to you by a doctor or received with a prescription, you must consult with the doctor in question or an equally qualified Health Care Professional prior to using any nutritional supplementation.
If undergoing medical therapies, then consult with your respective Therapist or Health Care Professional about possible interactions between your Treatment, any Pharmaceuticals or Drugs being given, and possible nutritional supplements or practices hosted on Examine.
Join Examine. Don't miss out on the latest nutrition and supplement research Enter your email and we'll keep you on top of the latest nutrition research, supplement myths, and more. I'm ready to learn. It is thought to reduce the risk of cardiovascular events, but is fairly underresearched.
0コメント